Saina Nehwal's campaign at the Japan Open ended in the second round when the world No. 1 went down to unseeded Minatsu Mitani of Japan 13-21, 16-21 on Thursday.
Mitani, currently ranked 18, in the first round defeated India's PV Sindhu in the first round on Wednesday. After Saina's loss, India's challenge in the women's singles comes to an end, with Jwala Gutta and Ashwini Ponnappa also out of the tournament.
India's HS Prannoy was also knocked out in the second round. The Indian lost to Korea's Lee Dong Keun 9-21, 16-21 in 43 minutes.
Reigning Commonwealth Games champion P Kashyap will face Third seed K Srikanth. In the only official match between the two Indians in the past, Kashyap came out on top in the final of the India Grand Prix Gold in January, beating Srikanth 23-21, 23-21.