A new study has revealed that damage in retinal periphery closely matches with the loss of blood
flow in diabetic people.
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A latest scientific study revealed that damage in retinal periphery closely matches the loss of blood flow in people with diabetes.
According to Joslin Diabetes Center's Beetham Eye Institute people with diabetic retinopathy have the presence of lesions in the periphery of their retina which increases the risk of diabetes rapidly. This causes loss of retinal blood flow called retinal "non-perfusion" caused by loss of small blood vessels or capillaries.
In the recent research, the scientists used ultra-wide-field (UWF) imaging to examine the eyes of 37 patients with diabetes and varying levels of retinopathy ranging from no disease to very advanced disease.
UWF retinal imaging can view more than 80 per cent of the retina in a single image. In comparison, traditional clinical retinal imaging combines seven smaller photos to cover about a third of the retina, says ophthalmologist Paolo Silva.
Areas of non-perfusion were identified by UWF retinal angiography, which detects blood flow after patients are injected with a fluorescent dye. The areas of non-perfusion matched up very closely with the peripheral lesions detected when these patients' eyes were scanned by normal UWF imaging, he emphasizes.
The most surprising result was how very closely associated these two areas seemed to be, says senior author Lloyd Paul Aiello.
He says that discovery raises the possibility that clinicians might be able to use the peripheral lesions to estimate the extent and location of the non-perfusion damage and the risk of disease progression without necessarily resorting to UWF angiography in every case.
The study appears in Ophthalmology.